Some 40 million people remain under weather alerts. In areas north of Interstate 90, up to 8 inches of snow could fall, with extra ice expected in some places, creating hazardous travel.
The storm will begin moving out of the northeast late Friday afternoon into the early evening.
State police said two lanes are closed on the Mass Pike east in Auburn after a tractor-trailer rolled over, the station said.
And affiliate WFXT reporter Vicki Graf tweeted video of a minor crash, also without injuries.
Officials urged people to avoid driving if possible.
“Heavy snow rates of 1” to 2” per hour will make travel difficult into the early afternoon,” the prediction center reported.
Connecticut Gov. Ned Lamont directed all state offices to close Friday and told staff to work remotely if possible.
“I strongly encourage everyone in Connecticut to stay off the roads on Friday morning unless absolutely necessary, particularly during the height of the storm so that DOT (Department of Transportation) crews can clear the roads and keep everyone safe,” Lamont said in a news release.
A mix of heavy precipitation ranging from 4 to 8 inches of snowfall and a light glaze of ice is expected in Hartford on Friday, according to CNN meteorologist Robert Shackelford. Snow can change to sleet and freezing rain during the late morning and back to snow by the afternoon, he said.
In Massachusetts, Gov. Charlie Baker also urged people to stay off the roads, warning them that plummeting temperatures could cause flash freezing and icy roads, particularly in areas that see the wintery mix of rain and sleet.
The storm’s path
More than 7 inches of snow had fallen in parts of Maine, New York state and Massachusetts by late Friday morning.
According to the forecasts, Boston can expect up to a foot of snow that will peak in the morning hours, potentially falling 1 to 2 inches per hour, similar to the rest of New England. The city is under a storm warning through Friday.
Meanwhile, up to 1 inch of a mix of snow and sleet is expected to fall on New York City roads. Farther north in Buffalo, New York, the storm could dump 8 inches of snow, in addition to sleet and freezing rain.
Heavier snow may be seen in Portland, Maine, where between 6 and 9 inches are expected, and another 8 to 11 inches are forecast for Concord, New Hampshire, throughout Friday.
And as for Midwestern cities, about 4 inches of snow are in store for Detroit, Milwaukee and Indianapolis. A wintry mix is expected in Cleveland and Columbus, Ohio, as well as Springfield, Illinois.
Some weather alerts have been discontinued in the Midwest since the storm has moved out. Freezing rain continued to fall in parts of Arkansas, Tennessee and Ohio.
Rain is expected to continue in the Southeast and mid-Atlantic.
CNN’s Amy Simonson contributed to this report.